Number of entries: 739   

Number of circRNAs: 661

Number of diseases: 100

Last Update: March 31, 2018


March 31, 2018, the CircR2Disease has been updated.

January 30, 2018, the CircR2Disease was formally launched

Contact us

Xiujuan Lei, No. 620, West Chang'an Avenue

Chang'an District, Xi'an 710119, China


Welcome to CircR2Disease

Circular RNAs (circRNAs) are widely expressed in diverse eukaryotic species and are characterized by covalently closed RNA loops through backsplicing events. They are known to function as miRNA sponges, regulators of alternative splicing, transcription factors and protein-coding templates for translation. To date, dysregulation of circRNAs have been associated with a group of diseases, i.e. various cancer. Here, CircR2Disease curated a database for experimentally supported associations between circRNAs and diseases, providing a platform for investigating mechanism of the disease-related circRNAs.

How to use CircR2Disease

-Browse the corresponding entries by circRNA name or disease name

-Search the corresponding entries by circRNA name, region, gene symbol,disease name or species

-Download all experimentally supported circRNA-disease associations

-Submit new entries into the CircR2Disease database

-Help user can get a detailed usage of CircR2Disease

The application of CircR2Disease

- Help users quickly find their interesting relationship between circRNAs and diseases

- Explore the appropriate algorithms or models for the circRNA-disease associations

- Investigate the function and molecular mechanisms of circRNAs in diseases

- Identify novel disease-related biomarker and drug targets